TRANSCRIPTION CYCLE LAB
Discovery and Targeting of Novel Regulators of RNA Polymerase II in Cancer
We are the Vervoort Lab, an interdisciplinary Scientific Research Laboratory at the Walter and Eliza Hall Institute (WEHI) in Melbourne, Australia. We aim to identify novel fundamental mechanisms of RNA Polymerase II (RNAPII)-mediated gene regulation in normal conditions and explore how these can be dysregulated in the context of cancer. Our goal is to identify critical vulnerabilities in cancer cells and exploit these therapeutically. Our research uses advanced genomics technologies and genome-wide CRISPR-screening technologies which we combine with bioinformatics analyses methods and relevant pre-clinical cancer models.
From Textbook Knowledge to Disease Understanding and novel Therapeutics
RESEARCH & DISCOVERIES
DISCOVERING NOVEL RNA POLYMERASE II REGULATORY FACTORS
We use various CRISPR screening methods combined with biosensors and targeted small-molecule inhibitors to identify genes involved in RNAPII regulation.
UNDERSTANDING TRANSCRIPTIONAL DYSREGULATION IN CANCER
We aim to develop an understanding of how these novel transcriptional regulatory mechanisms may be dysregulated in cancer through high-throughput transcriptomic profiling efforts.
THERAPEUTIC TARGETING OF TRANSCRIPTIONAL DEPENDENCIES IN CANCER
We identify critical transcriptional dependencies in cancer and explore ways to target these with novel small-molecule inhibitors through drug discovery efforts.
CONTACT US
1G, Royal Parade, Parkville VIC 3052, Level 6W
Epigenetics and Development Division
+61393452892
